Abcam, ab249741, Anti-SFXN5 antibody [EPR9532] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal SFXN5 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR9532,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab249741 is the carrier-free version of
ab172971
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Sideroflexin 5 commonly known as SFXN5 is a protein that acts mechanically as an inner mitochondrial membrane transporter. It belongs to the sideroflexin family of proteins and has a molecular weight of approximately 35 kDa. SFXN5 shows expression in various tissues including the heart brain and skeletal muscle reflecting its important function in cellular metabolism and energy production.
Biological function summary
SFXN5 contributes to the regulation of mitochondrial iron homeostasis and amino acid metabolism. This protein integrates into a larger complex involved in the translocation of specific substrates across the mitochondrial membrane. By modulating iron levels within mitochondria SFXN5 assists in maintaining cellular iron balance which is necessary for proper mitochondrial function and energy bioavailability.
Pathways
SFXN5 exerts influence on the heme synthesis and iron-sulfur cluster pathways. The transportation and regulation functions of SFXN5 relate closely to these pathways supporting the synthesis of heme groups and iron-sulfur clusters that are essential for numerous enzymatic processes. SFXN5 works in connection with proteins like frataxin and mitoferrin which also play roles in iron regulation and mitochondrial function.
SFXN5 has relevance to conditions like neurodegenerative diseases and anemia. Abnormalities in iron transport and homeostasis within mitochondria can contribute to the pathogenesis of these disorders. Proteins involved in related pathways such as ferritin and transferrin further connect with SFXN5 and are significant in understanding disease mechanisms involving disrupted iron metabolism. Understanding SFXN5's role in these contexts could offer insights into potential therapeutic approaches.