Abcam, ab250430, Anti-RRP4 antibody [EPR13605] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal RRP4 antibody. Carrier free. Suitable for ICC/IF, IP, WB, IHC-P and reacts with Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR13605,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:IHC-P, ICC/IF, WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab250430 is the carrier-free version of
ab181211
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RRP4 also known as RRP4 homolog is a component of the exosome complex a multi-protein complex involved in RNA processing. RRP4 plays an important mechanical role in RNA degradation and it is essential for maintaining RNA stability by facilitating the 3' to 5' exonucleolytic trimming of RNA molecules. This protein has a molecular mass of approximately 26 kDa and is widely expressed in the nucleus and cytoplasm where it participates in various RNA processing tasks.
Biological function summary
RRP4 performs an important role in RNA metabolism and is a vital constituent of the exosome complex which is responsible for RNA processing degradation and surveillance. The exosome complex acts in RNA quality control targeting malformed RNAs for degradation. RRP4 contributes to rRNA processing and maturation by forming stable interactions within the nucleolus. This activity ensures the accuracy and functionality of ribosomal RNA supporting the cell's protein synthesis machinery.
Pathways
RRP4 plays a critical function in the RNA processing pathways and is involved in rRNA and mRNA turnover. RRP4 interconnects with pathways involving exosome components like RRP6 and DIS3 which also contribute to RNA decay. Processing of rRNA by mechanisms involving RRP4 ensures the quality of ribosome assembly which is essential for translation and cellular homeostasis.
Improper function of the exosome complex including RRP4 associates with neurological conditions such as pontocerebellar hypoplasia and certain forms of cancer. RRP4 alongside proteins like RRP6 and DIS3 can accumulate mutations affecting exosome functionality. This can lead to disrupted RNA processing and accumulation of faulty RNA products contributing to disease pathogenesis. Understanding these interactions is vital for developing therapeutic approaches targeting such conditions.