Abcam, ab250591, Anti-Bora antibody [EPR11610] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal BORA antibody. Carrier free. Suitable for ICC/IF, IP, WB and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR11610,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:ICC/IF, IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab250591 is the carrier-free version of
ab182149
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Bora protein also known by its aliases Bora Rabbit or Bora Compliance plays a significant role in cell cycle regulation. It is a cofactor that primarily interacts with Aurora A kinase to promote activation. Bora protein weighs around 58 kilodaltons and is notably expressed in various tissues including those involved in cell division activities such as the reproductive organs and the skin.
Biological function summary
Bora protein's primary role involves cell cycle progression and the maintenance of genomic integrity. It forms part of a regulatory complex that ensures proper mitotic entry linking it closely with mitotic spindle formation and centrosome maturation processes. The Bora protein is pivotal in activating Aurora A kinase therefore ensuring accurate chromosome segregation during mitosis.
Pathways
The Bora protein is deeply integrated into cell cycle regulation and mitotic spindle checkpoint pathways. It functions as an upstream regulator within the Aurora A kinase pathway impacting downstream processes that involve key proteins such as Plk1 and Cdc25B. Through these interactions Bora protein helps monitor and coordinate entry into mitosis highlighting its centrality in mitotic timing and fidelity.
Abnormal expression or mutations in the Bora protein can lead to tumorigenesis and cancer progression. Specifically it is associated with disorders such as breast cancer and ovarian cancer. The dysregulation of Bora's interaction with Aurora A kinase and other proteins like p53 can contribute to aberrant cell cycle progression highlighting its involvement in the pathogenesis of cancer.