Abcam, ab250956, Anti-TXNDC11/EFP1 antibody [EPR14314] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal TXNDC11/EFP1 antibody. Carrier free. Suitable for IP, WB and reacts with Human, Mouse, Rat samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR14314,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human, Mouse, Rat,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:Based on the sequence analysis, this antibody recognizes 2 isoforms with the predicted MWs of 111KDa and 108KDa, respectively.

Product details:
ab250956 is the carrier-free version of
ab188329
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TXNDC11 also known as EFP1 is a thioredoxin domain-containing protein with a molecular mass of approximately 119 kDa. This protein acts as a disulfide isomerase involved in protein folding and redox regulation. TXNDC11 localizes mostly in the endoplasmic reticulum where its expression helps maintain cellular redox homeostasis. Recent studies also indicate expression in various tissues which suggests a role in broader cellular mechanisms.
Biological function summary
The redox regulation function of TXNDC11 contributes to the maturation and stabilization of nascent proteins. It appears to interact with other proteins in a complex manner to facilitate these processes. TXNDC11 mediates the formation and rearrangement of disulfide bonds serving as a chaperone that assists in proper protein folding which is essential for maintaining cell function and viability.
Pathways
TXNDC11 integrates into the protein processing pathways within the endoplasmic reticulum. It plays a role in the unfolded protein response (UPR) pathway important for managing ER stress. Proteins such as BiP/GRP78 and protein disulfide isomerase (PDI) work in conjunction with TXNDC11 to ensure proper protein folding under stress conditions highlighting its pathway integration.
TXNDC11's malfunction or misexpression links to diseases involving protein misfolding such as neurodegenerative disorders and certain cancers. Its roles in redox mechanisms and ER stress responses also connect it to insulin resistance syndromes. Interactions with proteins like IRE1 and CHOP suggest a significant role in these pathological conditions making it a potential target for therapeutic research.