Abcam, ab250989, Anti-NSG2 antibody [EPR15389(B)] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal NSG2 antibody. Carrier free. Suitable for WB and reacts with Mouse, Human, Rat samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR15389(B),
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab250989 is the carrier-free version of
ab189513
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NSG2 also known as Neuronal Vesicle Trafficking Associated 2 is a protein involved in intracellular processes. It has a molecular mass of approximately 49 kDa. NSG2 predominantly expresses in the brain particularly in neurons which suggests its critical role in neural activity. The protein localizes in synaptic vesicles hinting at its involvement in synaptic functions. Its expression is tightly regulated during neuronal development indicating its potential role in neural differentiation and maturation.
Biological function summary
The NSG2 protein contributes to vesicle trafficking within neuronal cells. It plays a part in a multiprotein complex that may regulate synaptic vesicle cycling or neurotransmitter release. The protein influences synaptic structure and function important for neural communication. Researchers have observed its significant impact on maintaining synaptic plasticity suggesting its role in learning and memory processes.
Pathways
NSG2 participates in neural development and synaptic communication pathways. It interacts within the neurotransmitter release cycle specifically affecting the synaptic vesicle cycle. In this context proteins such as SNAP-25 and synaptotagmin may have close interactions with NSG2 through these pathways. These interactions highlight the significance of NSG2 in neural circuit stability and function impacting neuronal transmission efficiency.
NSG2 has associations with neurological conditions including autism spectrum disorder and schizophrenia. Altered expression or mutation of NSG2 links it with these cognitive and developmental disorders. The protein's interactions with other targets like SNAP-25 and synaptotagmin might play a part in the manifestation or progression of these conditions. Understanding NSG2's role in these disorders could contribute to the development of therapeutic strategies.