Abcam, ab251035, Anti-OLF1 antibody [EPR15972] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal OLF1 antibody. Carrier free. Suitable for WB and reacts with Human, Rat, Mouse samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR15972,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab251035 is the carrier-free version of
ab190792
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
OLF1 also known as OLF-1-like protein or Olfactory neuron specific factor 1 functions mainly as a transcription factor. It weighs approximately 34 kDa and is primarily expressed in neurons and tissues related to the olfactory system. OLF1 binds specific DNA sequences to regulate the transcription of genes involved in olfactory receptor expression. It plays a critical role in the development and function of the olfactory system by influencing gene networks specific to olfactory receptors.
Biological function summary
OLF1 impacts the expression of olfactory receptor genes by interacting with other transcription factors within the nucleus. It functions as part of larger transcriptional complexes to modulate olfactory receptor gene expression. Through these activities OLF1 contributes significantly to the regulation of sensory perception in mammals. Its precise role in olfactory development and sensory neuron identity highlights its importance in neural biology.
Pathways
OLF1 is integrated into the olfactory signaling pathway. It cooperates with proteins like O/E-1 and O/E-3 to regulate olfactory receptor gene clusters. This regulation is important for odor detection and signal transduction in the olfactory pathway. The olfactory signaling pathway involves multiple stages including ligand binding and signal transduction in which OLF1 contributes through its transcriptional regulatory functions.
Alterations in OLF1 activity have been linked to anosmia a condition characterized by the loss of smell. Researchers also explore its involvement in neurodegenerative disorders where olfactory deficits are early symptoms such as Parkinson’s disease. Examining OLF1 interactions with proteins such as alpha-synuclein provides insights into its potential role in the pathogenesis of these conditions.