Abcam, ab251255, Anti-GRID2 antibody [EPR15422] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal GRID2 antibody. Carrier free. Suitable for WB and reacts with Rat, Mouse, Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR15422,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab251255 is the carrier-free version of
ab198499
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The gene symbol 'GRID2' encodes the protein Glutamate Receptor Ionotropic Delta-2 commonly called GRID2. It is part of the ionotropic glutamate receptor family and functions as ion channels in the central nervous system. GRID2 has an approximate mass of 110 kDa and is principally expressed in the cerebellum. This protein receptor plays a role in excitatory synaptic transmission by binding glutamate an essential neurotransmitter. It is not widespread in the body but has critical functions where it is present.
Biological function summary
The GRID2 protein is significant in synaptic plasticity and cerebellar functions by contributing to synapse formation and stability. It is part of the postsynaptic density (PSD) complex in neurons mainly affecting the communication between neuron cells. This protein helps in maintaining proper synaptic connections necessary for motor coordination and learning. The deficit of GRID2 can disrupt these functions affecting synaptic efficacy and neurological behavior.
Pathways
Grid ionotropic receptors like GRID2 play a pivotal role in the glutamatergic pathway and the synaptic signaling pathway. These pathways have strong associations with synaptic transmission and plasticity influencing learning and memory. The relationship of GRID2 with other proteins such as GRIA1 another glutamate receptor highlights its involvement in regulating synaptic strength and communication between neurons.
GRID2 mutations or dysfunctions link to neurological conditions such as spinocerebellar ataxia and autism spectrum disorders. Spinocerebellar ataxia patients show mutations that alter GRID2 function impacting motor coordination. In some autism spectrum disorder cases alterations in GRID2-supported pathways can influence synaptic connectivity which affects cognitive and social functioning. Connections with other proteins like GRIK2 suggest a network where GRID2 dysfunction contributes to these disease symptoms.