Abcam, ab251398, Anti-PCDH11X antibody [EPR16916] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal PCDH11X antibody. Carrier free. Suitable for WB and reacts with Mouse, Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR16916,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab251398 is the carrier-free version of
ab203520
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PCDH11X also known as Protocadherin 11 X-linked is a protein encoded by the PCDH11X gene. It weighs around 170 kDa. This protein is expressed mainly in the brain with higher expression in cerebral cortices and hippocampus regions. PCDH11X belongs to the protocadherin family known for their role in cell adhesion. Mechanically it facilitates cell-cell interactions supporting neuronal connectivity and synapse formation.
Biological function summary
PCDH11X plays a critical role in neuronal development and differentiation. It engages in homophilic adhesion allowing neurons to communicate and establish complex networks. PCDH11X functions within synaptic junctions and contributes to maintaining neural circuitry. It often interacts with other protocadherins and is considered part of a larger adhesion protein complex which includes cadherins known to regulate cellular architecture.
Pathways
PCDH11X takes part in neural circuitry development and synaptic plasticity pathways. Notably it participates in the Wnt signaling pathway which is essential for neuronal patterning and connectivity. PCDH11X shares interaction with proteins such as beta-catenin which link cell adhesion molecules to the actin cytoskeleton further influencing signaling pathways related to neural morphogenesis.
PCDH11X shows relevance to neurodevelopmental disorders and mental health conditions like schizophrenia. Researchers notice alterations in PCDH11X expression linked to these conditions suggesting its importance in neuropsychiatric health. Additionally it is connected to the N-cadherin protein which also associates with cognitive disorders emphasizing its role in maintaining proper neural function.