Abcam, ab25146, Anti-MPEG1 antibody

Size: 100µg
Rabbit Polyclonal MPEG1 antibody. Suitable for WB and reacts with Mouse, Rat samples. Cited in 4 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Rat Mpeg1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Rat Mpeg1.Q9WV57,
Specificity:ab25146 recognises Mpg-1 (macrophage-specific gene, MSG, MPS1).

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 6.5Preservative: 0.1% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MPEG1 also known as Macrophage Expressed Gene 1 is a protein with a molecular mass of approximately 71 kDa. It shows expression mainly in macrophages and other immune-related cells. MPEG1 belongs to the perforin-like protein family and acts by forming pores in target membranes a critical mechanical action of its function. This allows MPEG1 to contribute to immune defense by enabling the transfer of antimicrobial substances across cellular membranes.
Biological function summary
MPEG1 participates in the immune response and exhibits bactericidal activity. It is involved in innate immunity and works closely with other proteins to eliminate pathogens. In addition to its individual function it may exist within larger protein complexes that enhance its bactericidal properties in immune cells. This involvement suggests a significant role in acting against microbial infections and influencing immune system dynamics.
Pathways
Several major processes integrate the functions of MPEG1. It plays a role in the antimicrobial pathway by interacting with other proteins such as P2X7 which is part of the purinergic signaling pathway. By forming pores MPEG1 aids in pathogen degradation and modulates inflammatory responses. MPEG1's interaction within these pathways suggests it connects with cellular mechanisms of microbial clearance and immune regulation.
Abnormalities in MPEG1 function correlate with conditions such as chronic inflammatory diseases and some immune deficiency disorders. Altered MPEG1 expression or activity can impact its role in controlling infection and inflammation leading to relevant health issues. Besides proteins like NLRC4 are connected with MPEG1 in biological processes related to disease states indicating a multilayered interaction in maintaining host defense and controlling inflammatory responses.