Abcam, ab251683, Anti-GRF2 antibody

Size: 100µL
Rabbit Polyclonal GRF2 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human RAPGEF1 aa 50-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human RAPGEF1 aa 50-250. The exact immunogen used to generate this antibody is proprietary information.Q13905

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GRF2 also known as GTP-binding protein GRF2 plays a mechanical role as a guanine nucleotide exchange factor (GEF) for the Rho family of small GTPases. It has a molecular mass of approximately 94 kDa. This protein assists in the exchange of GDP for GTP therefore activating Rho GTPases. GRF2 is highly expressed in brain tissue specifically in neurons indicating a role in neurological processes.
Biological function summary
GRF2 functions as a critical regulator of signal transduction pathways. It forms part of signaling complexes that transmit signals from receptors on the cell surface to intracellular effectors. Through its GEF activity GRF2 influences cytoskeletal reorganization which impacts cell morphology motility and growth. It interacts with other proteins such as ELMO1 to facilitate cellular responses to external stimuli.
Pathways
GRF2 integrates into the MAPK/ERK pathway amplifying signals that trigger cellular proliferation and survival. GRF2 also links to the Rho/ROCK pathway regulating actin dynamics and cellular architecture. Within these pathways GRF2 functions in concert with proteins such as Ras and RhoA ensuring effective transmission and modulation of signals that govern various cellular activities.
GRF2 has relevance to neurological and cancer-related conditions. In the context of neurological disorders alterations in GRF2 expression or function can contribute to the pathophysiology of conditions like schizophrenia. In cancer GRF2 may influence tumor progression linking to proteins such as Ras which is often mutated in various cancers. Understanding GRF2's role provides insight into its potential as a therapeutic target for these diseases.