Abcam, ab251739, Anti-PITPnm 3 antibody

Size: 100µL
Rabbit Polyclonal PITPnm 3 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human PITPNM3 aa 450-600.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PITPNM3 aa 450-600. The exact immunogen used to generate this antibody is proprietary information.Q9BZ71

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PITPnm 3 also known as phosphatidylinositol transfer protein cytoplasmic 1 has a mass of around 40 kDa. This protein functions by transferring phosphatidylinositol and phosphatidylcholine between membranes playing a role in lipid metabolism. It is expressed in various tissues including the brain liver and placenta. The presence of PITPnm 3 is important in maintaining proper membrane lipid composition and signaling pathways within these cells.
Biological function summary
The function of PITPnm 3 extends to regulating intracellular signaling by managing lipid interfaces. It supports the formation and dynamics of membrane structures which are necessary for vesicular trafficking and membrane curvature. The protein operates as part of the phosphoinositide signaling complex aiding in membrane identity and compartmentalization. Its role is essential for normal cellular communication and organelle function.
Pathways
The involvement of PITPnm 3 extends to the phosphoinositide cycle and the inositol lipid signaling pathway. This protein interacts with phospholipase C and Akt contributing to the production of secondary messengers which mediate various cellular responses including proliferation and survival. Such interactions link PITPnm 3 to signaling cascades that are important for maintaining cellular homeostasis and response to environmental stimuli.
The dysregulation of PITPnm 3 activity has been associated with neurodegenerative diseases like Alzheimer's disease and metabolic disorders such as diabetes. Misregulation can affect lipid signaling and membrane trafficking contributing to disease pathogenesis. The relationship between PITPnm 3 and proteins like tau in Alzheimer's or insulin signaling components in diabetes highlights its significant role in disease mechanisms. Understanding these connections aids in developing targeted therapeutic strategies.