Abcam, ab251779, Anti-S100A14 antibody

Size: 100µL
Rabbit Polyclonal S100A14 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human S100A14 aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human S100A14 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.Q9HCY8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
S100A14 also known as BCMP84 is a calcium-binding protein belonging to the S100 family with a molecular mass of about 11 kDa. This protein is expressed mainly in epithelial tissues including lung kidney and colon. On the molecular level S100A14 interacts with cytoskeletal components and participates in the regulation of cell shape and motility. By binding to calcium ions it undergoes conformational changes that enable interaction with specific target proteins affecting various cellular processes.
Biological function summary
The function of S100A14 involves modulation of cellular proliferation and migration and it plays a role in tumorigenesis. It does not form part of a larger complex but it influences cell behavior through its interaction with receptor proteins on the cell surface and in the cytoplasm. Its actions at the cellular level can contribute to the transformation processes seen in cancer impacting aspects like cell adhesion and invasion.
Pathways
S100A14 has connections to the MAPK/ERK signaling pathway and the NF-kB signaling pathway. These pathways are central to the regulation of cell growth and apoptosis. Within these pathways S100A14 may interact with proteins like ERK1/2 and NF-kB affecting the downstream signals that control cell cycle and inflammatory responses. Its modulation of these pathways can influence responses to external stimuli and potentially contribute to aberrant cell behavior in cancer.
S100A14 has a notable relationship with cancer particularly in colorectal and breast cancers. Its overexpression correlates with tumor progression and metastasis in these cancers. Through its role in the MAPK/ERK pathway it relates to proteins such as KRAS and BRAF which are key modulators in oncogenic processes. Understanding the interaction of S100A14 in these pathways can aid in the development of therapeutic strategies targeting tumorigenesis.