Abcam, ab251867, Anti-ITPKA antibody

Size: 100µL
Rabbit Polyclonal ITPKA antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Mouse, Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Inositol-trisphosphate 3-kinase A aa 300-400.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Inositol-trisphosphate 3-kinase A aa 300-400. The exact immunogen used to generate this antibody is proprietary information.P23677

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ITPKA or inositol-trisphosphate 3-kinase A is an enzyme known for adding a phosphate group to inositol 145-trisphosphate (IP3) forming inositol 1345-tetrakisphosphate (IP4). The protein weighs approximately 51 kDa and plays an important role in regulating calcium signaling within cells. ITPKA expression is highly found in the brain where it influences various neuronal functions. ITPKA has an important role in the nervous system due to its enzyme activity.
Biological function summary
ITPKA participates in modifying phosphoinositide signaling by altering IP3 and IP4 levels. This protein does not form part of a larger complex but acts independently to influence calcium released from intracellular stores. By altering levels of IP3 ITPKA indirectly influences cellular activities like synaptic plasticity and neuronal excitability. Its kinase activity has links to other cellular functions which are less well-defined but suggest involvement in broader cellular processes.
Pathways
ITPKA participates in the inositol phosphate metabolism and postsynaptic density pathways. It plays an essential part in modulating the release of calcium through its interaction with IP3 important for various downstream effects. ITPKA has associations with proteins such as IP3 receptors due to its enzymatic products. This interaction is also important for further downstream effects in signaling pathways affecting cellular functions like synaptic strength and plasticity.
ITPKA has associations with neuropsychiatric disorders and cancer. Aberrant ITPKA levels have links to psychiatric disorders due to impacts on neuronal signaling and plasticity. In cancer ITPKA may influence cell proliferation and migration potentially through its downstream effect on calcium signals. Other proteins such as phospholipase C connect to ITPKA activity in pathways altered in these conditions highlighting the broader impact of its enzymatic activity in disease contexts.