Abcam, ab251961, Anti-EDG6/S1PR4 antibody

Size: 100µL
Rabbit Polyclonal EDG6/S1PR4 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human S1PR4 aa 1-50.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human S1PR4 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.O95977

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
EDG6 also known as S1PR4 is a G protein-coupled receptor that specifically binds sphingosine 1-phosphate (S1P). It has a molecular mass of approximately 42 kDa. It is mostly expressed in lymphoid tissues including the spleen and thymus as well as in certain blood cells like lymphocytes. S1PR4 plays a role in regulating immune cell behavior by influencing their migration proliferation and survival processes.
Biological function summary
S1PR4 impacts immune cell signaling and homeostasis. The receptor is a part of the sphingosine 1-phosphate receptor complex family which includes several other receptors like S1PR1 S1PR2 S1PR3 and S1PR5. S1PR4's activity affects lymphocyte circulation and localization playing a part in immune surveillance and response. Its expression pattern suggests importance in the adaptive immune system's regulation through intricate cellular signaling mechanisms.
Pathways
S1PR4 integrates into the S1P signaling pathway and the immune system signaling network. It interacts with proteins such as S1PR1 and S1PR3 contributing to the regulation of immune cell trafficking and vascular stability. These pathways help mediate immune response escalation or dampening as well as maintaining lymphatic endothelial barrier function. Such pathways emphasize S1PR4's role in controlling immune and vascular systems.
S1PR4 involvement suggests a link to autoimmune disorders and lymphomas. In autoimmune disorders abnormal S1P signaling through S1PR4 may result in improper lymphocyte migration contributing to disease progression. In lymphomas S1PR4 expression and interaction with other proteins like S1PR1 can influence tumor cell trafficking and survival. Understanding S1PR4's network offers potential therapeutic opportunities for these conditions.