Abcam, ab2521, Anti-Blood Group A Antigen antibody [HE-193]

Size: 1mL
Mouse Monoclonal ABO antibody. Suitable for Agg, IHC-P and reacts with Human samples. Cited in 4 publications.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:HE-193,
Isotype:IgM,
Light chain type:unknown,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, AggSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Specificity:This antibody recognizes human blood group A (monofucosyl and difucosyl A antigens with chain types 1, 2, 3, 4, 5, 6) and Forssman antigen.

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Purification notes-Concentrated by ultrafiltration (100 kDa cut-off). Actual immunoglobulin concentration not determined., Storage buffer-Constituents: Tissue culture supernatant, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Blood Group A Antigen also known as the A antigen is associated with the ABO blood group system. It is a glycoprotein located on the surface of red blood cells and various other cell types. The A antigen is characterized by its unique carbohydrate moiety which presents a specific sequence of monosaccharides. The A antigen has a molecular mass close to 100 kDa. Expression of the A antigen varies among individuals being found in those with blood type A and AB as well as in certain epithelial tissues and secretions.
Biological function summary
This antigen plays a significant role in human blood typing influencing transfusion compatibility and organ transplantation. It is not part of a larger molecular complex yet it interacts with antibodies specific to blood type. The presence of the A antigen is a factor in the immune response particularly with the generation of anti-B antibodies in individuals with blood type A. This interaction is an integral part of the body's defense mechanisms helping to determine self from non-self.
Pathways
The A antigen is central to the ABO antigen system a major pathway influencing immune reactions. This system involves the action of glycosyltransferase enzymes such as the A transferase which assist in the synthesis of the A antigen. These enzymes share relation with the B transferase in the pathways differing only in substrate specificity. Besides cross-reactions involving these antigens mediate the interactions with certain infectious agents incorporating them into the innate immune response.
The A antigen carries associations with transfusion reactions and hemolytic disease of the newborn. In transfusion reactions incompatibility between donor and recipient blood types results in destruction of red blood cells involving complement proteins. The A antigen also impacts susceptibility to certain infections like H. pylori as its presence can enhance bacterial adherence. Understanding the relationships between antigens and these conditions assists in developing therapies and compatibility matches.