Abcam, ab2525, Anti-Blood Group A1B Antigen antibody [HE-24]

Size: 1mL
Mouse Monoclonal ABO antibody. Carrier free. Suitable for Agg and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Native Full Length Protein corresponding to Human Histo-blood group ABO system transferase.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:HE-24,
Isotype:IgM,
Light chain type:unknown,
Carrier free:Yes,
Reacts with:Human,
Applications:AggSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Native Full Length Protein corresponding to Human Histo-blood group ABO system transferase.P16442,
Specificity:This antibody recognises human blood group A 1 B antigen. It does not detect A 2 B antigen.

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Purification notes-Concentrated by ultrafiltration (100 kDa cut-off). Actual immunoglobulin concentration not determined., Storage buffer-Constituents: Tissue culture supernatant, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Blood Group A1B Antigen also called A1B positive is a carbohydrate determinant located on red blood cells. It has a molecular mass of approximately 43 kDa. This antigen is expressed as part of the glycoconjugates on the surface of erythrocytes. It represents a combination of A and B antigenic determinants which are both involved in the ABO blood group system. The A1B blood type includes both A1 and B antigens making a person with this type a universal plasma recipient and compatible for transfusions with other A B or AB types.
Biological function summary
The Blood Group A1B Antigen plays a significant role in determining blood type and compatibility in transfusions. It does not form part of a larger complex but directly influences the interaction between erythrocytes and recipient’s immune system. The presence of both A and B antigens confers a unique immune profile as the individual’s serum naturally lacks anti-A and anti-B antibodies. This immunological property is central to its function as the blood type has implications for transfusions and organ transplants.
Pathways
Blood group antigens including A1B have roles in cellular adhesion and signaling pathways. They are involved in the complement system where they can influence elements like C3 convertase. Additionally proteins such as galectins interact with these antigens potentially altering cell-cell communication and cellular recognition processes. These pathways highlight the interaction between red blood cells and immune system components demonstrating the importance of ABO antigens in immune regulation.
Individuals with the A1B blood type may have distinctive health implications. They have higher risk factors associated with thrombosis potentially related to interactions between blood group antigens and coagulation pathways. Moreover there is a noted relationship with increased susceptibility to certain infections as some pathogens exploit blood group antigens for host attachment. Proteins such as von Willebrand factor an important component of the coagulation cascade may show altered interactions in individuals with the A1B antigen affecting hemostatic balance.