Abcam, ab252720, Anti-Norovirus GI.1 antibody [B1928M]

Size: 250µg
Mouse Monoclonal Norovirus GI.1 antibody. Carrier free. Suitable for ELISA and reacts with Norovirus samples. Cited in 1 publication. Immunogen corresponding to Virus preparation containing Norovirus GI.1 protein.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:B1928M,
Isotype:IgG2a,
Light chain type:kappa,
Carrier free:Yes,
Reacts with:Norovirus,
Applications:ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:Recognizes Norovirus virus-like particle (VLP) from GI.1 Norwalk, GI.3 Desert Shield, GI.4 Chiba.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Purification notes-Purified from tissue culture supernatant., Storage buffer-Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Norovirus GI.1 also known as Norwalk virus represents a single-stranded RNA virus that belongs to the Caliciviridae family. This virus comprises approximately 7.6 kilobases and expresses non-structural proteins including NS1/2 NS3 NS4 and NS5 as well as the key structural protein VP1. VP1 assembles into a capsid forming the protective shell of the virus. The mass of the Norovirus capsid protein is estimated to be around 58 kDa. Norovirus infects the epithelial cells of the small intestine where it triggers a cascade of immune responses.
Biological function summary
Norovirus influences gastrointestinal function through its ability to disrupt the normal absorption processes in the small intestine. It forms part of a quaternary structure that facilitates its binding to histo-blood group antigens present on the surface of gastrointestinal epithelial cells. This interaction initiates viral entry leading to cell infection and replication. Norovirus actively modulates the host cell machinery to enhance its replication resulting in alteration of intestinal permeability and motility.
Pathways
Norovirus GI.1 plays a significant role in the signaling pathways that control the immune response and cell death. The virus interacts with proteins such as STAT1 and IRF3 that involve in the host's innate immune response. Norovirus can modulate and at times evade these signaling pathways to ensure its survival and proliferation. Additionally the virus influences pathways related to the host's interferon response aiming to suppress antiviral activities and maintain infection.
Norovirus is significant to the development of acute gastroenteritis which leads to symptoms like vomiting and diarrhea. This virus impacts millions of individuals worldwide and can severely affect the elderly and immunocompromised individuals. The viral protein VP1 interacts with and modulates components like the intestinal enzymes and transport proteins that are essential for nutrient passage and absorption. Understanding these relationships helps develop effective therapeutic strategies targeting Norovirus infections.