Abcam, ab252726, Anti-Norovirus Major Capsid Protein antibody [B1938M]

Size: 250µg
Mouse Monoclonal Norovirus Major Capsid Protein antibody. Carrier free. Suitable for ELISA and reacts with Norovirus samples. Cited in 1 publication. Immunogen corresponding to Virus preparation containing Norovirus Major Capsid Protein protein.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:B1938M,
Isotype:IgG1,
Carrier free:Yes,
Reacts with:Norovirus,
Applications:ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:Recognizes Norovirus virus-like particle (VLP) from GI and GII, specific for a conserved epitope of the major capsid protein.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Purification notes-Purified from tissue culture supernatant. > 85% pure (size-exclusion chromatography)., Storage buffer-Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Norovirus Major Capsid Protein also known as VP1 plays a central role in the formation of the viral capsid a protective shell that encases the viral RNA. It has an approximate molecular mass of 58 kDa. This protein assembles into icosahedral structures that are critical for the virus structure and infectivity. Expression of VP1 occurs in infected host cells where newly synthesized viruses are produced.
Biological function summary
The major capsid protein of norovirus ensures the protection of viral genetic material and facilitates attachment to host cell receptors. Although VP1 is not part of a complex itself it oligomerizes to form the full capsid structure. By doing so VP1 allows the virus to survive in the host environment aiding in the viral entry into host cells and subsequent replication within them.
Pathways
The Norovirus Major Capsid Protein interacts with host cell receptor binding pathways which are essential for viral entry. It is closely associated with endocytic pathways that facilitate internalization into the cell. VP1's interaction with cellular receptors such as histo-blood group antigens plays a major role in these pathways highlighting its significance in viral infection processes.
Norovirus infections are a common cause of acute gastroenteritis worldwide. The capsid protein VP1 is critical in determining virulence and host specificity. It connects with other viral proteins in the replication complex influencing disease progression. Understanding the interactions and role of VP1 can aid in developing therapeutic strategies against norovirus-linked diarrheal diseases.