Abcam, ab252748, Anti-RSV antibody [B1537M]

Size: 250µg
Mouse Monoclonal RSV antibody. Suitable for ELISA and reacts with Respiratory syncytial virus samples.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:B1537M,
Isotype:IgG2b,
Carrier free:No,
Reacts with:Respiratory syncytial virus,
Applications:ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Specificity:F protein of Respiratory Syncytial Virus. Reactive with surface domain of both mature RSV virions and virion envelopes without formed inner nucleocapsid structures. Does not react with Influenza A (H1N1), Influenza A (H3N2), Influenza B, Parainfluenza 1, 2, 3 and Adenovirus.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Purification notes->90% pure (SDS-PAGE) Sourced from tissue culture supernatant., Storage buffer-Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Respiratory Syncytial Virus (RSV) is a single-stranded RNA virus with a mass of approximately 15000 kDa. It primarily infects the epithelial cells in the respiratory tract. RSV is well-studied due to its ability to fuse with host cells facilitating the entry of its nucleocapsid into the cytoplasm. This fusion process involves the RSV F protein an important virulence factor which triggers membrane fusion at neutral pH. The G protein of RSV which attaches to host cells is also important for its infectivity and cell entry aiding its transmission and pathogenicity.
Biological function summary
The virus is a significant pathogen in infants and the elderly causing respiratory illnesses. It is a part of the Pneumoviridae family and is known for inducing strong inflammatory responses in the lower respiratory tract. During infection RSV manipulates host cellular mechanisms such as the innate immune response to proliferate. It is not a part of a complex but interacts with host cell receptors through the G protein which attaches the virus to the host initiating a cascade of cellular interactions critical for infection.
Pathways
RSV disrupts typical immune signaling particularly interfering with the toll-like receptor (TLR) signaling pathway. This alteration allows the virus to evade the host's innate immune system. Additionally the RSV infection modulates the NF-kB pathway which plays a role in inflammation and immune regulation. RSV's interaction with these pathways can influence cytokine production and inflammatory responses with impacts on related proteins like TLRs and NF-kB inhibitors.
RSV is a major cause of bronchiolitis and pneumonia in young children and can exacerbate asthma and chronic obstructive pulmonary disease (COPD) in adults. The infection often leads to severe respiratory symptoms which result from the immune response to the virus. RSV's connection with diseases relates to proteins such as interleukins and other pro-inflammatory cytokines which can be significantly elevated during severe infections. Understanding these connections offers potential pathways for therapeutic interventions.