Abcam, ab252769, Anti-Parainfluenza Virus Type 3 Hemagglutinin antibody [B289M]

Size: 250µg
Mouse Monoclonal HN antibody. Suitable for ELISA and reacts with Human respirovirus 3 samples. Cited in 1 publication.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:B289M,
Isotype:IgG2a,
Carrier free:No,
Reacts with:Human respirovirus 3,
Applications:ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Purification notes->90% (SDS-PAGE). Sourced from Tissue Culture Supernatant., Storage buffer-Preservative: 0.0975% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Parainfluenza Virus Type 3 Hemagglutinin also called HA3 facilitates the virus's entry into host cells. It binds to sialic acid on the cell surface starting the infection process. This protein approximately 60 kDa in mass is integral to the viral envelope where it forms spikes. Expression occurs predominantly in the envelope of Parainfluenza Virus Type 3 organisms essential for its function in attachment and subsequent fusion to host cells.
Biological function summary
This hemagglutinin mediates attachment and fusion of the virus with host cell membranes. It serves as an important component of the envelope glycoprotein complex collaborating with other viral proteins to promote efficient host cell entry. By facilitating membrane fusion the hemagglutinin enables the transfer of viral RNA into the host cell setting the stage for viral replication and propagation within the host.
Pathways
Parainfluenza Virus Type 3 Hemagglutinin takes part in the viral entry pathway. It closely interacts with the fusion protein F another important viral envelope protein to execute successful membrane fusion. Together they ensure the release of viral RNA making it a vital part of the viral infection and replication cycle. Understanding these interactions can provide insights into viral propagation mechanisms and potential targets for intervention.
Parainfluenza Virus Type 3 Hemagglutinin is primarily associated with respiratory illnesses such as bronchiolitis and pneumonia. It plays a significant role in the pathogenesis of these conditions by facilitating viral invasion in respiratory epithelial cells. The hemagglutinin's interaction with host proteins is critical in initiating infection highlighting its potential as a therapeutic target for reducing disease severity and transmission.