Abcam, ab252839, Anti-LST1 antibody [7E2]

Size: 100µg / 1mg
Rat Recombinant Monoclonal LST1 antibody. Suitable for WB, IHC-P and reacts with Human, Mouse, Rat samples.
Key facts
Host species:Rat,
Clonality:Monoclonal,
Clone number:7E2,
Isotype:IgG2b,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Want a custom formulation?
This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Lymphocyte-Specific Transcript 1 (LST1) also known as leukocyte-specific transcript 1 is a small protein with a mass of approximately 7 kDa. This protein is primarily found in immune cells such as macrophages and dendritic cells as well as in the tissues linked to the immune system including lymph nodes and the spleen. LST1 acts mechanically by participating in cell adhesion and can influence immune cell migration.
Biological function summary
The LST1 protein contributes to immunological responses playing a significant role in modulating inflammatory processes. It is not usually considered as part of a known protein complex; however it associates with cytoskeletal elements during the immune response. The protein aids in the regulation of cytokine production impacting how immune cells communicate during an immune event or inflammation.
Pathways
LST1 is involved in key immune signaling cascades notably the NF-kB pathway and the MAP kinase pathway. These pathways are important for transmitting signals that control the expression of genes involved in immune and inflammatory responses. LST1 interacts with proteins such as NF-kB and ERK both of which are integral to the pathways it functions within supporting the regulation of immune cell function and survival.
Dysfunction or aberrant regulation of LST1 can relate to autoimmune diseases such as rheumatoid arthritis and inflammatory bowel disease. In these conditions improper LST1 function may contribute to the dysregulation of immune responses. Through these diseases it connects with proteins like TNF-alpha and interleukin-6 both of which are known to be critical in inflammation and immune regulation. Understanding LST1's involvement can aid in developing therapeutic strategies for immune modulation.