Abcam, ab252960, Anti-JWA antibody

Size: 100µL
Rabbit Polyclonal JWA antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ARL6IP5 aa 50-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ARL6IP5 aa 50-150. The exact immunogen used to generate this antibody is proprietary information.O75915

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
JWA also known as GTRAP3-18 or ADDCL is a protein with a molecular mass of approximately 37 kDa. Mechanically JWA functions in detoxification processes as it enhances the capacity of cells to combat oxidative stress. This protein exhibits a wide expression pattern across various tissues including the liver and the nervous system. JWA operates in both the cytoplasm and nucleus and dynamically shuttles between these cellular compartments.
Biological function summary
JWA interacts with signaling molecules to modulate cellular responses particularly in stress and repair processes. As a part of multi-protein complexes it collaborates with components like ERK (extracellular signal-regulated kinase) to influence cell survival and proliferation. JWA's involvement extends to regulating cytoskeletal elements affecting cellular movements important for tissue repair and immune responses.
Pathways
JWA integrates into the MAPK/ERK signaling pathway and the ATRA (all-trans retinoic acid) pathway. In these pathways JWA associates with proteins such as MEK1/2 and enhances their activity to promote cell differentiation and combat cellular apoptosis. The interaction of JWA with protein kinases exhibits its integral role in transmitting signaling molecules' instructions necessary for cellular development processes.
JWA shows a connection to cancer and neurodegenerative disorders. In cancer biology JWA's modulation of signaling pathways affects tumor growth interacting with proteins like p53 to induce cell cycle arrest and apoptosis. In the context of neurodegenerative disorders JWA helps mitigate oxidative stress and interacts with proteins involved in neuronal integrity suggesting a protective role against conditions like Alzheimer's disease.