Abcam, ab253009, Anti-Sec31A antibody

Size: 100µL
Rabbit Polyclonal Sec31A antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SEC31A aa 600-800.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SEC31A aa 600-800. The exact immunogen used to generate this antibody is proprietary information.O94979

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Sec31A also known as Secretory 31 homolog A is an important component in the process of vesicle formation within cells. It has a molecular mass of about 137 kDa. This protein primarily localizes to the endoplasmic reticulum (ER) exit sites where it plays a role in the transport of proteins. It functions in close association with the COPII (coat protein II) vesicle coat complex which is necessary for transporting proteins from the ER to the Golgi apparatus.
Biological function summary
Sec31A participates in the export of properly folded proteins from the ER. As part of the COPII complex Sec31A works with other proteins like Sec13 to form a cage-like structure encapsulating the transport vesicle. This event is important for maintaining protein homeostasis and efficient cellular operations. Sec31A's involvement ensures that proteins reach their correct destinations impacting overall cell health.
Pathways
He protein has significant involvement in the ER-to-Golgi transport pathway. In this pathway features an important interaction between Sec31A and Sar1 a small GTPase that initiates COPII assembly. The function of Sec31A is critical here as it allows the progression of cargo through the secretory pathway. This pathway is integral to many cellular processes including the proper secretion of hormones and enzymes.
Alterations and dysfunction in Sec31A have been linked to heart-related conditions and neurological disorders. Mutations in this protein can result in faulty protein transport leading to an accumulation of misfolded proteins and stress in the ER. Additionally disruptions in Sec31A activity have shown connections with the accumulation of neurodegenerative disorders. The relationship between Sec31A and Sec13 could further elucidate understanding of these conditions due to their collaborative role in vesicle formation and transport.