Abcam, ab253016, Anti-Elongation of very long chain fatty acids protein 3 antibody

Size: 100µL
Rabbit Polyclonal Elongation of very long chain fatty acids protein 3 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ELOVL3 aa 1-50.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ELOVL3 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.Q9HB03

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Elongation of very long chain fatty acids protein 3 also known as ELOVL3 is involved in the elongation process of fatty acids. It is a member of the endoplasmic reticulum membrane-bound proteins responsible for extending saturated and monounsaturated fatty acids with 18 to 24 carbons. With a molecular mass of approximately 31 kDa ELOVL3 is expressed strongly in tissues related to lipid metabolism such as liver brown adipose tissue and skin. This distribution displays its role in organisms’ overall lipid homeostasis.
Biological function summary
The synthesis and regulation of very long chain fatty acids rely heavily on ELOVL3. The protein is part of a complex that includes other elongation enzymes important for lipid metabolism. Through its action in lipid biosynthesis ELOVL3 plays an essential role in maintaining cellular membrane integrity and signaling molecules that rest within the lipid categories. This underlines its importance in energy storage and consumption particularly in adipose tissues where it contributes to the synthesis of lipids necessary for efficient thermal insulation and protection.
Pathways
Long chain fatty acid metabolism places significant importance on ELOVL3. It aligns itself within the fatty acid elongation pathway which serves as an integral section of the overall lipid metabolism pathway. This process involves interaction with other elongase proteins like ELOVL1 revealing a network of collaborative pathway members performing tasks necessary for elongating fatty acids properly. This elongation impacts processes like synthesis of essential neutral lipids and the development of ceramides that affect cellular communication.
Particular implications for ELOVL3 exist in metabolic conditions specifically in disorders such as Ichthyosis and Adrenoleukodystrophy. Misregulation or mutation of ELOVL3 can lead to abnormal lipid profiles in affected tissues contributing to these diseases. For instance disturbances in ELOVL3 activity alter the formation of lipid components that impair skin barrier function which is key for Ichthyosis. Connections with proteins such as ABCD1 involved in Adrenoleukodystrophy reveal how alterations in pathways concerning ELOVL3 influence disease progression further illustrating how dysfunction impacts human health.