Abcam, ab253024, Anti-K25 antibody

Size: 100µL
Rabbit Polyclonal K25 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human KRT25 aa 1-50.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human KRT25 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.Q7Z3Z0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
K25 also known as Protein kinase 25 is a serine/threonine protein kinase with a molecular weight of approximately 57 kDa. This protein plays a role in several cellular processes by regulating signal transduction pathways. K25 shows expression mainly in tissues such as the brain heart and skeletal muscle. This localization can influence its involvement in cellular activities specific to these tissues.
Biological function summary
K25 contributes to the regulation of cell cycle and apoptosis. It acts within a complex environment interacting with other kinases and regulatory proteins to promote cell growth and response to stress signals. Its activity modulates the phosphorylation states of different substrates impacting signaling cascades that steer cell proliferation and programmed cell death.
Pathways
K25 is involved in the MAPK signaling pathway and the p38 MAPK pathway. These pathways are important for controlling cell differentiation and response to external stimuli like cytokines or stress. K25 interacts closely with proteins such as MEK and ERK within these signaling cascades to execute cellular responses and maintain homeostasis.
K25 has been linked to cardiovascular diseases and neurodegenerative disorders. In cardiovascular conditions alterations in K25 expression or function can disrupt normal heart activity potentially through interactions with proteins such as p38 MAPK. In neurodegenerative diseases the dysregulation of K25-related signaling may contribute to neuronal cell death associated with other proteins involved in apoptosis and cell survival.