Abcam, ab2541, Anti-XIAP antibody

Size: 50µg
Rabbit Polyclonal XIAP antibody. Suitable for WB and reacts with Human samples. Cited in 14 publications. Immunogen corresponding to Synthetic Peptide within Human XIAP.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human XIAP. The exact immunogen used to generate this antibody is proprietary information.P98170,
Specificity:This antibody detects the 53 kDa human XIAP protein. It does not cross-react with other apoptosis inhibitors.

Product details:
This product is manufactured by BioVision, an Abcam company and was previously called 3183 XIAP Antibody.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.01% Thimerosal (merthiolate)Constituents: PBS, 30% Glycerol (glycerin, glycerine), 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
XIAP also known as X-linked inhibitor of apoptosis protein is a member of the inhibitor of apoptosis protein (IAP) family. XIAP has a molecular mass of approximately 57 kDa. This protein inhibits apoptosis by binding to and inhibiting caspases particularly caspase-3 caspase-7 and caspase-9. XIAP expresses in a variety of tissues including the heart kidney and liver but also shows expression in cancer cells. Its role in inhibiting cell death makes it a significant focus for cancer research.
Biological function summary
The function of XIAP involves regulation of apoptosis an important process in maintaining cellular homeostasis. It forms part of the apoptosome complex by interacting with caspases to prevent premature cell death. XIAP serves to protect cells from stress-induced apoptotic signals helping in survival under adverse conditions. This ability makes it a subject of interest in studying cancer survival mechanisms since overactive XIAP can allow cancer cells to avoid programmed cell death.
Pathways
Apoptosis regulation and cell survival pathways prominently feature XIAP. Particularly XIAP plays a role in the intrinsic apoptotic pathway which is activated in response to internal stress signals. XIAP regulates this pathway via its interaction with caspase-9 and interactions with other proteins such as Smac/DIABLO which can antagonize XIAP's function. This interaction is key in balancing cell death and survival therefore highlighting its role in apoptosis control.
XIAP's dysregulation links to cancer and neurodegenerative disorders. Overexpression of XIAP can contribute to cancer by enabling cells to evade apoptosis leading to uncontrolled cell proliferation. Moreover studies have suggested a role in neurodegenerative diseases where alterations in XIAP may affect neuronal cell survival. In these contexts XIAP's interactions with proteins such as caspases and Smac/DIABLO surface as important in understanding how apoptosis evasion or enhancement contributes to disease pathology.