Abcam, ab254147, Anti-RHOG antibody [1F3-RHOG]

Size: 20µg / 100µg / 1mg
Mouse Recombinant Monoclonal RHOG antibody. Suitable for ICC/IF, IP, WB and reacts with Mouse, Human, Rat samples. Cited in 1 publication.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:1F3-RHOG,
Isotype:IgG2b,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, IP, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Want a custom formulation?
This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RHOG also known as ras homolog gene family member G is a small GTPase with a molecular mass of approximately 21 kDa. It belongs to the Rho family which plays a role in various cellular functions. RHOG is highly expressed in hematopoietic cells with significant presence in macrophages and neutrophils. This protein is also found in various tissues where it assists in cell movement and cytoskeletal rearrangements.
Biological function summary
RHOG regulates cell shape and motility. It is involved in forming membrane protrusions such as filopodia and lamellipodia. RHOG can act as a part of a protein complex with other GTPases. It controls actin cytoskeleton dynamics by activating pathways needed for cell migration and chemotaxis. This protein significantly aids immune cell function during immune surveillance and inflammatory responses.
Pathways
RHOG interacts with diverse signaling cascades. It activates the Rac1 pathway influencing cellular migration and growth processes. RHOG collaborates with proteins like PI3-kinase in these pathways contributing to the regulation of cytoskeletal organization. RHOG involvement in these signaling networks ensures cells respond aptly to external cues maintaining cellular integrity and function.
RHOG is implicated in cancer and chronic inflammatory diseases. Abnormal RHOG expression or activity can lead to excessive cell movement and invasion often linked to cancer metastasis. Additionally it relates to chronic inflammatory responses where dysregulation may exacerbate disorders such as rheumatoid arthritis. In these conditions RHOG interacts with proteins like RhoA to mediate changes in cell behavior that drive disease progression.