Abcam, ab254566, Anti-ZIP7 antibody

Size: 100µg
Rabbit Polyclonal ZIP7 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Rat, Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human SLC39A7 aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SLC39A7 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.Q92504

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZIP7 also known as SLC39A7 is a zinc transporter protein that plays a role in regulating zinc homeostasis within cells. It encodes a protein weighing approximately 56 kDa. ZIP7 is located on the membrane of the endoplasmic reticulum and the Golgi apparatus. It facilitates the release of stored zinc into the cytosol where zinc acts as an essential cofactor for various cellular processes. Expressions of ZIP7 can be found widely across different tissues with significant levels in the liver brain and pancreas.
Biological function summary
ZIP7 influences intracellular signaling and cellular functions by regulating zinc levels. While not part of a complex ZIP7 is involved in activating protein kinases that require zinc for their function including tyrosine kinases. Increased intracellular zinc levels due to ZIP7 activity can signal the activation of MTF1 a transcription factor important for metal homeostasis. ZIP7 by affecting these signaling cascades participates in critical processes like cellular growth and division.
Pathways
Zinc release through ZIP7 integrates into important signaling pathways like the MAPK and PI3K-AKT pathways. In these pathways ZIP7 interacts with proteins such as ERK and AKT which are vital for cell proliferation and survival. ZIP7's regulation of zinc availability therefore ties it closely to the control of cellular responses that depend on these pathways for growth and differentiation.
Disruptions in ZIP7 function link to conditions such as cancer and neurodegenerative diseases. ZIP7's misregulation has associations with breast cancer where altered zinc signaling influences cancer cell proliferation and metastasis. Furthermore Alzheimer's disease connects to ZIP7 through disturbances in metal homeostasis in neurons which are critical for neuronal function and health. Understanding ZIP7's role in these diseases could provide insights for therapeutic strategies targeting zinc homeostasis.