Abcam, ab254597, Anti-ZFPL1 antibody

Size: 100µL
Rabbit Polyclonal ZFPL1 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ZFPL1 aa 100-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ZFPL1 aa 100-300. The exact immunogen used to generate this antibody is proprietary information.O95159

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZFPL1 also known as Zinc Finger Protein-Like 1 is a protein with a mass of approximately 50 kDa. It is expressed in various tissues with noticeable presence in the testis and lungs. Functionally ZFPL1 has a C2H2-type zinc finger domain which suggests its role in DNA binding and potentially in gene regulation processes. These characteristics of ZFPL1 indicate its involvement in cellular transcriptional activities.
Biological function summary
The ZFPL1 protein plays a role in regulating gene expression. It is part of a protein complex that interacts with nuclear transcription factors influencing the expression of genes involved in cell growth and differentiation. This function highlights its importance in maintaining cellular development and adaptation by ensuring that gene expression patterns meet the cell's physiological needs.
Pathways
ZFPL1 engages in biological processes related to transcriptional regulation and the Wnt signaling pathway. It interacts with transcriptional co-regulators to modulate gene expression. The protein's relationship with other components of the Wnt pathway such as beta-catenin indicates its importance in signaling events that control cell fate decisions and proliferation. This involvement emphasizes its role in the processes that require precise orchestration of gene expression.
ZFPL1's altered function associates with certain cancer types and developmental disorders. The protein's involvement in transcriptional regulation links it to cancer pathways where alterations can lead to unchecked cell growth. Mutations or dysregulation of ZFPL1 sometimes occur in connection with proteins such as APC known to play a role in colorectal cancer. Also its role in cell differentiation might contribute to its implication in developmental disorders where proper gene expression is essential for normal cellular development.