Abcam, ab254601, Anti-ZBTB38 antibody

Size: 100µL
Rabbit Polyclonal ZBTB38 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Zinc finger and BTB domain-containing protein 38 aa 650-850.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Zinc finger and BTB domain-containing protein 38 aa 650-850. The exact immunogen used to generate this antibody is proprietary information.Q8NAP3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The ZBTB38 protein also known as CIBZ (CTCFL interacting BTB zinc finger protein) functions as a transcriptional regulator with a molecular mass of approximately 149 kDa. It contains zinc finger motifs that bind to DNA sequences to modulate gene expression. ZBTB38 mostly localizes in the nucleus of cells and shows expression in human tissues such as brain heart and skeletal muscle. The presence in these tissues indicates an important role in fundamental cellular processes.
Biological function summary
The regulatory role of ZBTB38 impacts cell cycle control and differentiation. It participates in transcriptional repression or activation depending on the interacting partners. Known to form part of multisubunit complexes ZBTB38 can engage in molecular interactions that influence chromatin remodeling. Through these configurations it affects the transcriptional regulation of target genes influencing cellular functions and development pathways.
Pathways
ZBTB38 is involved in the regulation of the Wnt and MAPK signaling pathways. These pathways play a significant role in cell proliferation differentiation and survival. ZBTB38 directly interacts with proteins such as CTCF (CCCTC-binding factor) and CTCFL (CTCF-like) in these pathways influencing various cellular responses. The precise modulation of these pathways by ZBTB38 contributes to maintaining cellular homeostasis and dynamics.
Disruptions in ZBTB38 function are linked to certain cancers and developmental disorders. Abnormal expression or mutations in ZBTB38 are associated with an increased risk of neuroblastoma where it interacts with MYC a known oncogene. Additionally changes in ZBTB38 are connected with developmental syndromes possibly through its interactions with CTCF impacting gene expression profiles relevant to these conditions.