Abcam, ab254640, Anti-JTB antibody

Size: 100µL
Rabbit Polyclonal JTB antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human JTB aa 1 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human JTB aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.O76095

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
JTB also known as Jumping Translocation Breakpoint is a protein with a molecular mass of approximately 14 kDa. It is expressed widely in a variety of tissues with higher levels seen in certain cancers. Mechanically JTB interacts with several cellular structures and its role in the regulation of cell growth and apoptosis has been observed. This protein often localizes to the mitochondria which hints towards its involvement in energy and metabolic processes.
Biological function summary
The JTB protein plays an important role in promoting cell proliferation and survival. It is part of the transmembrane protein complex and is sometimes involved in cellular signaling pathways that manage these processes. Its activity impacts cellular responses to external stress and can contribute to the regulation of cell cycle progression. These roles are consistent with the observed overexpression of JTB in cancerous cells indicating its function in maintaining cell viability.
Pathways
JTB is involved in several signaling pathways that regulate fundamental cellular activities. It is prominently linked with the PI3K/Akt pathway a critical pathway for cell growth and survival. Through this pathway JTB interacts with Akt a significant protein that facilitates cell growth and proliferation. Another connection lies with the MAPK pathway where JTB interacts with key components that influence cell division and differentiation.
Several studies show that JTB has a notable impact on cancer progression particularly in prostate and colorectal cancers. JTB overexpression often correlates with poor prognosis in these cancers aligning with its role in promoting cell proliferation. Additionally JTB's interaction with caspases proteins essential for apoptosis ties it to disorders involving defective apoptosis such as cancer. Understanding these interactions can help target therapies that modulate JTB function and offer new treatment strategies.