Abcam, ab254654, Anti-ZFHX4 antibody

Size: 100µL
Rabbit Polyclonal ZFHX4 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Zinc finger homeobox protein 4 aa 400-600.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Zinc finger homeobox protein 4 aa 400-600. The exact immunogen used to generate this antibody is proprietary information.Q86UP3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZFHX4 also known as zinc finger homeobox 4 is a transcription factor involved in regulating gene expression. It has a molecular mass of approximately 384 kDa. This protein is large and contains multiple zinc finger domains allowing it to bind DNA and influence transcription of specific genes. ZFHX4 is widely expressed in human tissues with higher expression noted in the brain and eyes suggesting its important role in neural function and ocular development.
Biological function summary
ZFHX4 plays a role in neural development and maintenance. This transcription factor is not known to be part of a larger protein complex but it interacts with several other proteins to control neuronal differentiation and maturation. In the retina ZFHX4 influences the growth and specialization of neural cells. This role in cellular development highlights its importance in maintaining the normal function of neural tissues.
Pathways
ZFHX4 influences both the Wnt signaling and Notch signaling pathways which are critical in development and cellular differentiation. Within these pathways it interacts with proteins such as β-catenin in the Wnt pathway and Notch receptors in the Notch pathway. These interactions ensure proper functioning of the pathways facilitating cell proliferation and differentiation during development.
ZFHX4 associates with ocular diseases such as Axenfeld-Rieger syndrome and corneal dystrophy. Mutations or dysregulation of ZFHX4 can lead to developmental defects in the eye. In Axenfeld-Rieger syndrome ZFHX4 interacts with other transcription factors like FOXC1 affecting the development of the anterior segment of the eye. In corneal dystrophy the interruption in its regulation can lead to abnormal corneal cell function and vision impairment.