Abcam, ab254666, Anti-SG2NA antibody

Size: 100µL
Rabbit Polyclonal SG2NA antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human STRN3 aa 550-750.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human STRN3 aa 550-750. The exact immunogen used to generate this antibody is proprietary information.Q13033

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SG2NA also known as Serine/Threonine Phosphatase 2A regulatory subunit B'' is a component of the protein phosphatase 2A (PP2A) complex. SG2NA has a molecular mass of approximately 54 kDa. The protein functions as a regulatory subunit and influences the specificity and activity of the PP2A holoenzyme. SG2NA is expressed in various tissues with notable concentrations in the brain indicating its role in neuronal activities.
Biological function summary
This regulatory protein contributes to several cellular processes through its interaction as part of the PP2A complex. SG2NA plays a significant role in cell cycle regulation controlling cell proliferation and apoptosis. It is involved in dephosphorylating specific substrates that are essential for cellular signal transduction and maintaining protein stability. This control over phosphorylation events impacts cellular responses to external stimuli and internal signals.
Pathways
SG2NA interacts with many signaling cascades notably the PI3K/AKT and MAPK pathways. It regulates the reversal of phosphorylation in these pathways impacting cellular processes such as growth and survival. By modulating the activation states of proteins like AKT and ERK SG2NA indirectly affects complex networks of biological pathways and collaborates with protein partners like PP2A catalytic subunits to maintain cellular homeostasis.
Research has associated SG2NA with neurodegenerative diseases and cancer. Altered function or regulation of SG2NA links to disorders such as Alzheimer’s disease where the protein interacts with tau a related protein aggregating in neurofibrillary tangles. In cancer SG2NA interacts through pathways impacting proteins like p53 reflecting its role in tumor suppression. Understanding the role of SG2NA in these diseases can lead to insights into potential therapeutic targets.