Abcam, ab254693, Anti-SAMD4A antibody

Size: 100µL
Rabbit Polyclonal SAMD4A antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SAMD4A aa 550-650.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SAMD4A aa 550-650. The exact immunogen used to generate this antibody is proprietary information.Q9UPU9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SAMD4A also known as Smaug1 is a regulatory protein involved in mRNA turnover. This protein has an approximate mass of around 109 kDa. You can find SAMD4A expression in various tissues notably in the brain heart and skeletal muscle. It acts by binding to specific mRNA targets controlling their stability and translation. The presence of SAMD4A impacts how these target messages are processed indicating its role in post-transcriptional regulation.
Biological function summary
The function of SAMD4A in mRNA regulation plays an important role in cellular homeostasis. It interacts with components of the cellular machinery involved in mRNA decay and translation repression. Although it often functions independently SAMD4A can also be part of larger protein complexes involved in mRNA processing and degradation. Through these interactions it helps ensure that mRNA levels within cells remain balanced contributing to normal cellular function and development.
Pathways
SAMD4A is integrated within the mRNA surveillance and decay pathways. It directly impacts the nonsense-mediated mRNA decay (NMD) pathway a quality control system that identifies and degrades faulty mRNAs. SAMD4A's interaction with proteins such as UPF1 plays a significant role in this process. Additionally it can influence the translational repression pathway which regulates protein synthesis by controlling mRNA availability.
SAMD4A connects closely with neurological conditions and muscle-related diseases. Alterations in its expression or function have been linked to neuronal disorders like autism spectrum disorders. In muscle dysregulation of SAMD4A is associated with muscular dystrophy. Its partnership with proteins such as FMR1 in neurons and muscle fibers indicates its involvement in maintaining normal neurodevelopment and muscle function.