Abcam, ab254711, Anti-TSEN2 antibody

Size: 100µL
Rabbit Polyclonal TSEN2 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TSEN2 aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TSEN2 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.Q8NCE0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TSEN2 or tRNA splicing endonuclease subunit 2 is a protein that plays a role in the processing of tRNA molecules. It acts as a component of the tRNA splicing endonuclease complex aiding in the precise cutting of precursor tRNA to remove introns. TSEN2's molecular mass is approximately 54 kDa. This protein is expressed in various tissues in the human body with significant expression reported in tissues that perform high levels of protein synthesis like the brain and testes.
Biological function summary
The TSEN2 protein is involved in the maturation of transfer RNA molecules by forming part of the tRNA splicing endonuclease complex. This complex consists of four subunits: TSEN2 TSEN15 TSEN34 and TSEN54. The precise function of TSEN2 within this complex is to help identify and cut specific sites within the tRNA introns so the molecules can be correctly processed ensuring functional tRNAs are available for translation processes. The activities of TSEN2 are critical for maintaining the accuracy of protein synthesis in cells.
Pathways
The TSEN2 protein participates in the tRNA processing pathway which has implications for overall protein synthesis. This pathway is important for the maturation of tRNA and subsequent translation. Another pathway that TSEN2 is involved with is the RNA splicing pathway. Proteins related to this pathway include TSEN34 and TSEN54 which also play roles in removing introns.
Genetic alterations in TSEN2 are linked to conditions like pontocerebellar hypoplasia a neurological disorder characterized by brain development issues. Mutations that affect TSEN2 and its partner proteins in the endonuclease complex like TSEN54 can lead to improper tRNA processing contributing to the pathogenesis of this disorder. Additionally TSEN2 mutations have associations with disorders where neurological function and development are disrupted.