Abcam, ab254776, Anti-ZNF711 antibody

Size: 100µL
Rabbit Polyclonal ZNF711 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ZNF711 aa 50-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ZNF711 aa 50-200. The exact immunogen used to generate this antibody is proprietary information.Q9Y462

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZNF711 also known as Zinc Finger Protein 711 plays a role in transcriptional regulation. This protein contains multiple zinc-finger domains which allow it to bind to specific DNA sequences influencing gene expression by either activating or repressing transcription. ZNF711 has a molecular mass of roughly 92 kDa and is primarily expressed in the brain where it likely influences neural development and function.
Biological function summary
Zinc Finger Protein 711 functions within the DNA-binding transcription factor family. It interacts with other transcription regulators to modulate the expression of genes critical for brain development and function. ZNF711 does not usually act alone but as part of larger protein complexes which offer it the ability to exert broader gene regulatory functions. Being part of complexes enhances its role in fine-tuning gene expression patterns.
Pathways
ZNF711 is involved in the transcriptional regulation pathways including the retinoic acid signaling pathway. The protein interacts with other transcription factors such as those in the nuclear hormone receptor family. It may also influence pathways related to neural differentiation and synaptic transmission. Through these pathways ZNF711 orchestrates various stages of neural development and affects growth and functioning of neurons.
Mutations or dysregulation of ZNF711 links to X-linked intellectual disability which could affect synaptic signaling and neuronal communication. These mutations result in altered expression levels of key developmentally regulated genes. Additionally it may interact with proteins related to autism spectrum disorders like FMR1 which plays a role in synaptic plasticity. Disturbances in ZNF711 associated pathways can contribute to neurological impairments.