Abcam, ab254802, Anti-RDM1 antibody

Size: 100µL
Rabbit Polyclonal RDM1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human RDM1 aa 50-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human RDM1 aa 50-200. The exact immunogen used to generate this antibody is proprietary information.Q8NG50

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RDM1 also called RAD52 motif 1 is a protein that facilitates DNA repair processes. It has a molecular weight of approximately 41 kDa and appears in diverse tissues throughout the body. Researchers note its expression in the nucleus where it engages in repairing DNA breaks ensuring genomic stability. As part of a family of proteins involved in DNA repair RDM1 shares structural components but stands out due to specific motif involvement.
Biological function summary
RDM1 aids in the restoration of damaged DNA and participates in homologous recombination repair. It forms part of a complex that detects and responds to DNA damage contributing to cell cycle regulation. By working together with proteins like RAD52 RDM1 reinforces the cellular ability to manage genetic lesions enabling cells to maintain growth and replication integrity under stress conditions.
Pathways
The actions of RDM1 are integral to the DNA damage response pathway. This pathway links to mechanisms that control cell cycle checkpoints. The protein intersects with the homologous recombination repair pathway cooperating with other essential proteins such as BRCA2. These alliances highlight RDM1's role in shaping effective responses to genomic injury facilitating accurate DNA repair and preventing mutations.
Aberrations involving RDM1 have connections to cancer progression. Disruptions in its function lead to deficiencies in DNA repair and increased genetic instability contributing to tumorigenesis. Additionally RDM1-associated malfunction may also relate to neurodegenerative disorders given oxidative stress impacts DNA integrity. In cancer it shares interactions with proteins such as RAD51 highlighting its involvement in robust genomic maintenance.