Abcam, ab254850, Anti-L17 antibody

Size: 100µL
Rabbit Polyclonal L17 antibody. Suitable for IHC-P, WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human TPGS2 aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TPGS2 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.Q68CL5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
L17 also known as ribosomal protein L17 is an important component of the 60S subunit of the eukaryotic ribosome. It has a molecular mass of approximately 22 kDa. L17 is expressed in various tissues throughout the body with particularly high expression levels in rapidly-dividing cells. As a structural element of the large ribosomal subunit L17 plays a role in the core processes of protein synthesis.
Biological function summary
The function of protein L17 involves participation in the formation of the ribosome complex. It interacts with other ribosomal proteins and rRNA molecules to ensure the accurate assembly of the ribosome. This assembly allows the ribosomal machinery to facilitate efficient translation of mRNA into polypeptides which are subsequently folded into functional proteins essential for cellular functions and proliferation.
Pathways
The protein L17 engages with translation-related pathways notably the ribosomal biogenesis pathway and the mTOR signaling pathway. The mTOR pathway regulates cell growth and metabolism in response to nutrients stress and growth factors. As part of the ribosome L17 indirectly associates with proteins like RPL5 and RPL11 essential for ribosome biogenesis and function forming a link between ribosome assembly and cellular regulation.
Ribosomal protein L17 has implications in ribosomopathies such as Diamond-Blackfan Anemia which is characterized by impaired ribosome biogenesis and function. Mutations affecting L17 and its associated proteins such as RPL5 and RPL11 can disrupt normal ribosomal biogenesis leading to developmental abnormalities and increased susceptibility to specific cancers due to the imbalance in protein synthesis and cellular homeostasis.