Abcam, ab254895, Anti-YEATS2 antibody

Size: 100µL
Rabbit Polyclonal YEATS2 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human YEATS2 aa 50-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human YEATS2 aa 50-200. The exact immunogen used to generate this antibody is proprietary information.Q9ULM3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
YEATS2 also called Gas41 is a protein with a molecular weight of approximately 53 kDa. YEATS2 is part of the YEATS domain-containing protein family known for binding acetylated lysine residues on histone tails. It exhibits widespread expression in various human tissues suggesting its involvement in basic cellular processes. Structurally YEATS2 acts as a reader of histone modifications which is important in the regulation of gene expression.
Biological function summary
YEATS2 has roles in chromatin remodeling and transcription regulation by being part of the Ada2/Gcn5/Ada3 (ATAC) complex. This multi-protein complex is involved in acetylation of histones a modification that influences chromatin structure and gene activity. By interacting with chromatin YEATS2 assists in the loosening of DNA so that transcription machinery can access the genetic code. Through these interactions YEATS2 is critical in activating certain genes during developmental and differentiation processes.
Pathways
YEATS2 is involved in the regulation of gene expression and the transcriptional coactivation pathways. It interacts closely within the ATAC complex with other proteins like GCN5 a well-known histone acetyltransferase influencing the transcription regulation pathway. Additionally YEATS2 overlaps with mechanisms that control cell cycle progression impacting how cells grow and replicate. It does not work in isolation but participates in a web of interactions that define gene expression outcomes.
Studies show YEATS2 involvement in specific cancer types like lung cancer due to its links with dysregulated gene expression. Disruptions in its function or expression levels may contribute to tumorigenesis through pathways involving proteins like BRD4 another key player in chromatin organization and transcription regulation. Changes in YEATS2 activity could impact cellular processes leading to altered cell growth and division which are hallmarks of cancerous growth.