Abcam, ab254938, Anti-VGLL3 antibody

Size: 100µL
Rabbit Polyclonal VGLL3 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Transcription cofactor vestigial-like protein 3 aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Transcription cofactor vestigial-like protein 3 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.A8MV65

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
VGLL3 or Vestigial-like family member 3 is a co-transcriptional factor with an estimated molecular mass of around 35 kDa. Researchers often refer to it by its alternate name without confusion. The protein primarily exists in the nucleus where it interacts with other transcriptional elements to modulate gene expression. VGLL3 shows high expression in certain tissues including skin and immune cells indicating its functional importance in these regions. It can engage TEAD transcription factors to regulate target genes.
Biological function summary
VGLL3 regulates cellular processes related to development and immune response. It functions as a transcriptional co-activator and can be part of protein complexes involving TEAD proteins to influence gene transcription. This association impacts tissue growth and cellular differentiation highlighting VGLL3's role in maintaining cellular homeostasis. Its activity can impact cellular pathways that are critical for normal biological functioning.
Pathways
VGLL3 shows significant involvement in Hippo signaling and immune response pathways. The Hippo pathway plays an essential role in controlling organ size and suppressing tumors where VGLL3 interacts with proteins such as YAP and TAZ to control cellular proliferation. Additionally VGLL3's involvement in immune pathways suggests its role in regulating immune cell activity and response which may connect it with other immune-responsive genes or proteins.
VGLL3 plays a role in autoimmune diseases and certain cancers. For autoimmune diseases VGLL3 has been linked to conditions like systemic lupus erythematosus where it affects immune pathway regulation. In cancer VGLL3's impact on the Hippo pathway can influence tumor growth making it a target for research in tumorigenesis. Its interaction with TEAD proteins in both contexts suggests a broader functional implication in disorders involving abnormal cell growth and immune regulation.