Abcam, ab254986, Anti-Netrin G2 antibody

Size: 100µL
Rabbit Polyclonal Netrin G2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human NTNG2 aa 50-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human NTNG2 aa 50-150. The exact immunogen used to generate this antibody is proprietary information.Q96CW9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Netrin G2 also known as Netrin-G2 or NTNG2 is a protein that weighs approximately 61 kDa. Netrin G2 belongs to the Netrin family and operates through binding with its receptors. It is expressed mainly in the central nervous system particularly in the brain regions like cortex and hippocampus. The protein facilitates communication across nerve cells by directing axon guidance and maintaining synaptic plasticity.
Biological function summary
This protein plays an essential role in neuronal development and synaptic connections. Netrin G2 acts as a part of cell surface signaling modules allowing interaction with other molecular entities. It binds to Netrin G2 ligands which helps stabilize long-range axonal trajectories. Due to this function Netrin G2 contributes to maintaining proper neural circuit assembly necessary for cognitive functions.
Pathways
Netrin G2 plays a part in the axon guidance and synaptogenesis pathways. It interacts with other guidance cues proteins such as DCC (Deleted in Colorectal Cancer) and UNC5B (Unc-5 Netrin Receptor B) which also participate in the regulation of axonal mapping. Throughout these pathways it ensures neurons reach their correct destination therefore influencing neural map precision and adaptability.
Mutations or dysregulation of Netrin G2 have associations with neurological conditions like schizophrenia and autism spectrum disorders. Alterations in Netrin G2 might affect its interaction with related proteins like DCC in these conditions. These disruptions can contribute to improper brain function by interfering with typical pathways of axonal targeting and synaptic stability.