Abcam, ab25959, Anti-NDEL1 antibody

Size: 100µg
Rabbit Polyclonal NDEL1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 9 publications. Immunogen corresponding to Synthetic Peptide within Human NDEL1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human NDEL1. The exact immunogen used to generate this antibody is proprietary information.Q9GZM8,
Specificity:ab25959 recognises NDEL1.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NDEL1 also known as Nudel or nuclear distribution element-like 1 is a protein with a molecular mass of around 38 kDa. It plays a role mechanically by participating in microtubule and centrosome-related processes. In terms of expression NDEL1 is found in both the central nervous system and several peripheral tissues. Its localization relates to its function in cellular dynamics particularly involving the cytoskeleton.
Biological function summary
NDEL1 interacts within a multi-protein complex called the dynein motor complex. This association is critical for the process of neuronal migration and axonal transport involving the movement of cellular components along microtubules. The protein acts as a linking agent facilitating microtubule assembly and organization which are essential for maintaining cellular structure and function.
Pathways
The role of NDEL1 in cytoskeletal dynamics integrates into key pathways such as the cell cycle and neurodevelopmental processes. It interacts with proteins like LIS1 in the cell cycle pathway which affects mitosis. Moreover its interaction with dynein emphasizes its role in intracellular transport during neurodevelopment indicating its aosphysical involvement in brain architecture.
NDEL1 has a significant connection with neurodevelopmental disorders and neurodegenerative diseases. Its association with LIS1 and the disruption of their interaction contributes to lissencephaly a condition marked by smooth brain surface. Additionally alterations in NDEL1 function also connect with Alzheimer's disease due to its role in neuronal structural maintenance alongside proteins such as tau that become dysregulated.