Abcam, ab259884, Anti-GNAO1 antibody [EPR24151-69]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal GNAO1 antibody. Suitable for WB, IHC-Fr, IHC-P and reacts with Mouse, Rat, Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR24151-69,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-Fr, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GNAO1 also known as Guanine nucleotide-binding protein G(o) subunit alpha acts mechanically as part of the signaling processes within cells. It is a G protein alpha subunit that weighs around 41 kDa. The protein is widely expressed in neurons particularly affecting neurotransmitter signal transduction in brain regions like the cortex and hippocampus. GNAO1 is a part of the heterotrimeric G protein family that transduces signals from receptors on the cell surface to internal effectors playing a central role in signal processing.
Biological function summary
GNAO1 regulates the activity of various downstream effectors contributing to multiple cellular responses. It partners with beta and gamma subunits in forming a heterotrimeric G protein complex. The GNAO1's impact includes modulating neurotransmitter release influencing neuronal excitability and controlling other cellular processes like gene transcription. This protein's involvement in these processes highlights its necessity for normal neurological function and synaptic signaling.
Pathways
GNAO1 engages in critical molecular pathways such as the G protein-coupled receptor (GPCR) signaling pathway and the MAPK signaling pathway. It acts in concert with proteins like GNAI1 and GNB1 within these pathways contributing to a variety of cellular responses by transmitting signals received from extracellular ligands to initiate intracellular actions. GNAO1's activity in these pathways ensures proper signaling cascade required for normal cellular responses.
Mutations or dysfunctions of GNAO1 can lead to neurological conditions such as epileptic encephalopathy and movement disorders like dystonia. It relates closely to disorders through its interaction with proteins like GNB1 which also influence similar neurological diseases. These associations underline GNAO1's significance in maintaining neurological health shedding light on potential therapeutic targets for related disorders.