Abcam, ab259936, Anti-Neuroligin 1 + Neuroligin 3 + Neuroligin 2 + Neuroligin 4 antibody [EPR24149-36]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal Neuroligin 1 antibody. Suitable for WB, IHC-P and reacts with Recombinant full length protein - Human, Recombinant full length protein - Mouse, Mouse, Rat, Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR24149-36,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Neuroligin proteins including Neuroligin 1 Neuroligin 2 Neuroligin 3 and Neuroligin 4 serve as important synaptic cell adhesion molecules. They are mostly massed between 90-110 kDa and are alternatively referred to as NLGN1 NLGN2 NLGN3 and NLGN4 respectively. These proteins are expressed in the nervous system particularly in the synaptic clefts where they play a role in establishing and maintaining synapses between neurons. By interacting with neurexins they facilitate connections and communication between presynaptic and postsynaptic neurons.
Biological function summary
The neuroligin proteins are essential for synaptic organization and function. They act as part of the synaptic complex forming a bridge with neurexin proteins which are located on the presynaptic membrane. This complex ensures proper synaptic signaling and plasticity. Neuroligin 1 is mainly involved with excitatory synapses whereas Neuroligin 2 associates more with inhibitory synapses. Neuroligin 3 and 4 can modulate both types of synapses highlighting their versatile roles in synaptic regulation.
Pathways
Neuroligin proteins contribute significantly to the development and modulation of synaptic pathways. They are engaged in neurotransmission pathways which impact how neurons communicate with each other using chemical signals. Specifically they interact with the postsynaptic scaffold proteins like PSD-95 which are critical in the glutamatergic signaling pathway. Through these pathways neuroligins ensure the balance of excitatory and inhibitory signals maintaining a fine-tuned neuronal network.
Neuroligin proteins have a significant connection to autism spectrum disorders and schizophrenia. Variations in genes encoding these proteins can lead to improper synaptic function making it a research focus for understanding neurodevelopmental disorders. Additionally neuroligins have been linked with neuroligins-NRXN1 interactions in these diseases. Mutations or dysregulation in these proteins can disrupt standard synaptic operation emphasizing their role in neuropsychiatric conditions.