Abcam, ab26069, Anti-FOXN1 antibody

Size: 100µg
Goat Polyclonal FOXN1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human FOXN1 aa 600 to C-terminus.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human FOXN1 aa 600 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.O15353

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-This antibody was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: Tris buffered saline, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FOXN1 also known as Forkhead Box N1 is a transcription factor with an approximate mass of 48 kDa. It plays a role in regulating the expression of genes important for the development of certain tissues. FOXN1 is expressed predominantly in the thymus where it guides the differentiation of epithelial cells. Its expression is also observed in skin tissue implicating it in keratinocyte regulation.
Biological function summary
FOXN1 influences the differentiation and function of thymic epithelial cells which are essential for T-cell maturation. It does not associate with any specific protein complex but acts independently to modulate gene expression. By influencing these processes FOXN1 directly impacts immune function and epidermal integrity highlighting its significance in both immunity and skin health.
Pathways
FOXN1 is an important regulator within the T-cell development pathway impacting the maturation and selection of thymocytes. It aligns closely with the Wnt signaling pathway essential for cell proliferation and differentiation. Within these pathways FOXN1 interacts with other proteins like β-catenin an important mediator in Wnt signaling playing a role in cell fate determination.
Mutations or dysregulation of FOXN1 connect to immunodeficiencies and skin disorders. Nude/SCID phenotypes characterized by a lack of thymus and hair directly link to FOXN1 deficiency. Moreover alopecia a condition causing hair loss involves disruptions in FOXN1 signaling. Connections to other proteins such as CCL25 which impacts thymic development illustrate the broader implications of FOXN1 dysregulation in these conditions.