Abcam, ab26283, Anti-pan CEACAM antibody [TET2]

Size: 50µg
Mouse Monoclonal CEACAM5 antibody. Suitable for Flow Cyt and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Native Full Length Protein corresponding to Human CEACAM5.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:TET2,
Isotype:IgG2b,
Carrier free:No,
Reacts with:Human,
Applications:Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Native Full Length Protein corresponding to Human CEACAM5.P06731,
Specificity:ab26283 is a broadly reactive antibody which reacts with most of the CEACAM molecules characterized to date (except CEACAM3, CEACAM4 and CEACAM7)4. It can be used to detect CEACAM1 (BGP/CD66a), CEACAM5 (CEA/CD66e), CEACAM6 (NCA/CD66c) and CEACAM8 (CGM6/CD66b) on transiently transfected BOSC23 cells by flow cytometry.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-pH: 7.2Preservative: 0.01% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Pan CEACAM also known as Carcinoembryonic Antigen-related Cell Adhesion Molecule represents a group of glycoproteins. It carries a molecular weight varying between 60 to 90 kDa depending on the glycosylation extent. These molecules express mainly on epithelial cells especially those in the gastrointestinal tract and respiratory system. CEACAMs serve in cell-cell adhesion playing significant roles in maintaining tissue architecture and intercellular communication.
Biological function summary
These proteins participate in immunoregulation and cellular adhesion. CEACAMs function as part of larger multi-protein complexes at the cell surface interacting with numerous ligands and receptors to modulate immune responses. These proteins can inhibit or promote cellular processes such as proliferation differentiation and apoptosis. This way they help in maintaining normal cellular function and adaptation to environmental changes.
Pathways
Pan CEACAM proteins influence pathways related to cellular communication and immune response. They involve particularly in the JAK/STAT and MAPK pathways. CEACAMs participate in initiating or modulating cascade signaling which involves proteins like STAT3 and ERK contributing to versatile cellular responses. These pathways help fine-tune cellular proliferation and survival particularly in response to external stimuli or stress.
Pan CEACAMs hold significant implications in cancer and inflammatory diseases. Elevated CEACAM expression associates with several types of cancer including colorectal and lung cancer where it affects tumor progression and metastasis. It also connects with inflammatory bowel disease contributing to an altered immune response and epithelial damage. In these conditions CEACAMs interact with other proteins such as CEACAM1 and CEACAM5 influencing disease development and progression.