Abcam, ab262938, Anti-LMTK3 antibody

Size: 100µL
Rabbit Polyclonal LMTK3 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human LMTK3 aa 650-750.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human LMTK3 aa 650-750. The exact immunogen used to generate this antibody is proprietary information.Q96Q04

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LMTK3 also known as Lemur Tyrosine Kinase 3 is a protein kinase with a molecular weight of approximately 97 kDa. It occurs widely in various tissues notably in the brain lung and reproductive tissues. LMTK3 complements several cellular functions because it modifies other proteins by adding phosphate groups which modulate their activity. Its expression seems to vary according to tissue specificity and physiological conditions.
Biological function summary
The kinase influences many cellular processes including cell signaling and receptor modulation. LMTK3 does not appear to be a part of a larger protein complex but its function impacts numerous downstream signaling networks. Studies suggest that LMTK3 regulates estrogen receptor activity influencing cell proliferation and survival. This makes it a relevant protein in hormone-sensitive tissues and conditions.
Pathways
LMTK3 is involved in key cellular signaling pathways such as the ERK/MAPK and PI3K/AKT. Its activity is related to the regulation of proteins like AKT and ERK which are important for cell proliferation differentiation and survival. These pathways position LMTK3 as an important player in cellular response and adaptation to external and internal signals affecting how cells behave in response to growth factors and stress conditions.
Research associates LMTK3 with breast cancer and neurodegenerative diseases. In breast cancer LMTK3 interacts with estrogen receptors affecting tumor growth and resistance to some therapies. This highlights its potential as a therapeutic target in oncology. In neurodegenerative diseases LMTK3’s connection with proteins like tau suggests a role in neuronal survival and function providing insights into disease progression and possible interventions.