Abcam, ab262947, Anti-LH1 antibody

Size: 100µL
Rabbit Polyclonal LH1 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PLOD1 aa 300-400.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PLOD1 aa 300-400. The exact immunogen used to generate this antibody is proprietary information.Q02809

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LH1 also known as Luteinizing Hormone subunit beta plays an important mechanical role in reproductive biology. The molecular mass of LH1 is approximately 15 kDa. It is chiefly expressed in the anterior pituitary gland. This expression is essential for mediating reproductive processes by interacting with other hormones and receptors located in various tissues including the gonads. The activity of LH1 involves binding and signaling through specific hormone receptors therefore instigating a cascade of biological responses.
Biological function summary
LH1 engages in regulatory functions within the reproductive system facilitating ovulation and stimulating the production of sex steroids such as testosterone and estradiol. LH1 operates as part of a dimeric glycoprotein hormone complex which includes the alpha and beta subunits that also construct other glycoprotein hormones like TSH and FSH. This complex plays a fundamental role in orchestrating the hormonal milieu necessary for reproductive organ function and development.
Pathways
LH1 operates within the hypothalamic-pituitary-gonadal (HPG) axis. This pathway involves a series of hormonal signals starting from GnRH release from the hypothalamus prompting the synthesis and release of LH1 from the pituitary. Within this axis LH1 works in conjunction with related proteins like FSH to regulate reproductive functions. These pathways ensure proper feedback regulation of hormone levels important for maintaining reproductive health and function.
LH1 abnormalities have associations with reproductive conditions such as polycystic ovary syndrome (PCOS) and hypogonadism. In PCOS an imbalance in LH1 and FSH levels can disrupt normal ovarian function leading to symptoms like irregular menstruation and infertility. In hypogonadism LH1 levels may be insufficient to stimulate normal gonadal activity. Prolactin another hormone interacting in these disorders can also influence the functioning of LH1 adding complexity to the underlying pathophysiology.