Abcam, ab263466, Rab Family (RAB4, RAB5, RAB7, RAB8A, RAB9, RAB10) Antibody Sampler Panel

Size: 1Kit
Rab Family (RAB4, RAB5, RAB7, RAB8A, RAB9, RAB10) Antibody Sampler Panel (ab263466) is part of the multiplex kits range. Abcam offers high-quality biological reagents and tools including antibodies, proteins, assays, cell lines and lysates.
Key facts
Reacts with:Rat, Human, Mouse,
Target:RAB7ASee target data

Product details:
Rab Family (RAB4, RAB5, RAB7, RAB8A, RAB9, RAB10) Antibody Sampler Panel ab263466 contains multiple trial-sized versions of anti-human, mouse, and rat antibody clones against RAB7, RAB10, RAB8A, Rab5, Rab9 and Rab4 specifically selected for high performance in various applications. This panel contains 6 recombinant rabbit monoclonal antibodies against RAB7, RAB10, RAB8A, Rab5, Rab4, and Rab9. They are provided as a sampler panel to allow you to easily evaluate each antibody.
For guidelines on how to use each antibody within the panel, please consult the individual datasheet for each antibody.
Panel contains:
- Rabbit monoclonal [EPR7589] to RAB7 (20 μL)
ab137029
- Rabbit monoclonal [MJF-R23] to RAB10 (20 μL)
ab237703
- Rabbit monoclonal [EPR14873] to RAB8A (20 μL)
ab188574
- Rabbit monoclonal [EPR21801] to Rab5 (20 μL)
ab218624
- Anti-Rab9 antibody [EPR13272] - Late Endosome Marker (20 µL)
ab179815
- Rabbit monoclonal [EPR3043] to Rab4 - Early Endosome Marker (20 μL)
ab109009
Explore our range of antibody sample panels designed to provide you with a variety of trial-size antibodies in a convenient and cost-effective format.
Carrier-free formulations of our recombinant antibodies are also available for easy conjugation to labels of your choice and for multiplex applications. Use our intuitive search and select carrier-free or your label of choice. For bespoke conjugations or large volumes email bespoke@abcam.com.

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Rab proteins including Rab9 Rab4 Rab5 RAB7 RAB10 and RAB8A are small GTPases that regulate intracellular vesicle trafficking. Rab proteins play key roles in membrane transport processes and are involved in various stages of vesicle budding movement docking and fusion. Each Rab protein has a specific mass for example Rab5 has approximately 24 kDa. These proteins are expressed in numerous tissues often with overlapping yet distinct expression patterns. They serve as endosome markers and localize to specific membrane compartments specializing in aiding the maturation movement and fusion of vesicles within cells.
Biological function summary
These Rab proteins organize essential processes in cellular trafficking by interacting with effector proteins and elements of the cytoskeleton. They are integral to the formation of protein complexes required for vesicle tethering and fusion. Rab4 and Rab5 participate in early endosome dynamics coordinating endocytic pathways while RAB7 facilitates late endosome-lysosome trafficking. Rab9 assists in the movement of molecules from late endosomes to the trans-Golgi network. These proteins operate in concert ensuring precise regulation and timing in vesicular transport processes.
Pathways
Rab proteins influence an array of intracellular signalling networks vital for cellular homeostasis. Rab5 participates prominently in the endocytosis pathway interacting with proteins like EEA1 (Early Endosome Antigen 1) to regulate vesicle fusion and sorting. RAB7 is heavily involved in the endo-lysosomal pathway important for lysosome biogenesis. This interaction optimizes cellular recycling and degradation processes. Rab8A affects exocytosis and is implicated in the secretory pathway especially in the context of polarized trafficking working alongside proteins like Sec4/RAB8.
Mutations or dysregulation of Rab proteins can contribute to neurodegenerative disorders and cancer. Rab5 and its partners are tied to the pathology of Alzheimer's disease through their role in the endocytic pathway where impaired function may lead to amyloid-beta plaque formation. Alterations in RAB7 activity associate with Charcot-Marie-Tooth disease type 2B where defective vesicular trafficking impacts neuronal function. These associations underline the importance of Rab proteins not only in normal cellular processes but in disease states as well.