Abcam, ab263947, Anti-STAT6 (phospho Y641) antibody [EPR22599-78]

Size: 20µL / 100µL / 1mL
Anti-STAT6 (phospho Y641) antibody [EPR22599-78] (ab263947) is a rabbit monoclonal antibody detecting STAT6 in Western Blot, Flow Cytometry (Intra), Flow Cytometry, IP, Dot Blot . Suitable for Human, Mouse, Rat . - Biophysical QC for unrivalled batch-batch consistency - Over 20 publications
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR22599-78,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:Flow Cyt (Intra), Dot, WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:STAT6 is activated via phosphorylation at Tyr641 and is required for responsiveness to IL-4 and IL-13.

Product details:
What is this antibody validated in?
Anti-STAT6 (phospho Y641) antibody [EPR22599-78] (ab263947) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunoprecipitation (IP), Dot Blot in Human, Mouse, Rat samples.
What is the molecular weight of STAT6?
Anti-STAT6 (phospho Y641) [EPR22599-78] (ab263947) specifically detects a band for STAT6 (UniProt: P52633) at a molecular weight of 94kDa.
Trusted by the scientific community
Anti-STAT6 (phospho Y641) [EPR22599-78] (ab263947) was first used in a scientific publication in 2019 and has been cited over 20 times in peer-reviewed journals.
Trial sizes available!
Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 20µl.
Discover our selection of trial-size antibodies
Other related products
We have a range of other formats of antibody clone [EPR22599-78] also available for your convenience: ab263947, Carrier free -
ab263950
, PE -
ab305802
, APC -
ab305803
, HRP -
ab305804
, Alkaline Phosphatase -
ab308655
, Alexa Fluor
ab309630
, Alexa Fluor
ab309996
, Alexa Fluor
ab310359
, Alexa Fluor
ab311881
, Alexa Fluor
ab312350
, Alexa Fluor
ab321521
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
STAT6 also known as Signal Transducer and Activator of Transcription 6 is a transcription factor with a mass of around 94 kDa. This protein is an important component in the signaling pathways that respond to cytokines especially those of the IL-4 and IL-13 receptors. STAT6 mainly expresses in immune cells including T cells B cells and macrophages. It exists in the cytoplasm until the cytokine stimulation prompts its phosphorylation and translocation to the nucleus where it influences gene expression.
Biological function summary
STAT6 plays a central role in the development and function of Th2 cells a subset of T helper cells. The protein controls genes linked to the immune response and inflammation such as IL-4 and IL-13 by binding to specific DNA sequences as part of the transcriptional complex. These processes are critical for antibody class switching in B cells and also for regulating the differentiation of T cells which are processes important in defending against parasitic infections and are linked to allergies.
Pathways
STAT6 functions mainly in the JAK-STAT signaling pathway a pathway important for transmitting information from chemical signals outside cells to the cell nucleus resulting in DNA transcription. Within this pathway STAT6 works closely with JAK1 and JAK3 kinases which phosphorylate STAT6 enabling its activation. The protein also connects with other members of the STAT family like STAT1 and STAT3 during overlapping signaling processes.
STAT6 has associations with asthma and certain types of cancer such as colorectal cancer. In asthma STAT6 influences the production of IgE and eosinophilic inflammation often connected to allergic responses. Meanwhile STAT6 promotes tumorigenesis in some cancers by regulating genes responsible for cell survival and proliferation. It connects with proteins like IL-4 and IL-13 in these disorders which suggests potential therapeutic targets for treatment.